Hepatitis B Vaccine

Engerix B (glaxo)
Recombivax (merck)


Recombinant viral DNA



Pregnancy risk:

None apparent

Breast-feeding risk:


Recommended For:

Travelers to developing nations who plan to stay > than 4 weeks, receive medical/dental care, tattoos or engage in unprotected sex


Allergy to previous dose

Allergy to yeast

Current moderate-severe illness

Side effects:

Pain at injection site
Low grade fever or mild flu like symptoms


Amount: 1.0 ml(cc) for each injection
Route: Intramuscular injection in the shoulder
Number of doses: 3 doses
Schedule: 1st dose – day 0, 2nd dose – 1 month
3rd dose – 6 months


Ideally vaccine series should be completed 6 months prior to travel.
If that is not possible an accelerated schedule is followed with Engerix B
As follows:

1st dose – day 0, 2nd dose – 1 month, 3rd dose – 2 months with 4th dose – 12 months


Doses on days 0,7 and 21 and 12 months later (not FDA approved)

Hepatitis B Vaccine can be taken simultaneously with other vaccines, antibiotics and immune globulin products

For combination Hepatitis A and Hepatitis B Vaccines please see Twinrix.


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